Most trials included women older than 70 years.

Vitamin D could have been administered as supplemental vitamin D (vitamin D3 (cholecalciferol) or vitamin D2 (ergocalciferol)) or as an active form of vitamin D (1α-hydroxyvitamin D (alfacalcidol) or 1,25-dihydroxyvitamin D (calcitriol)). Taking into consideration pleyotropic vitamin D action and safety aspects serum 25-hydroxyvitamin D (25-OHD) level of 20-60 ng/ml (50-750 nmol/l) in children and 30-80 ng/ml (75-200 nmol/I) in adults is considered as optimal. Italian Society for Osteoporosis, Mineral Metabolism and Bone Diseases (SIOMMMS)].
 Prophylaxis on FP10 only recommended for institutionalised/housebound patients. All trials were conducted in high-income countries. USA.gov. Adami S, Romagnoli E, Carnevale V, Scillitani A, Giusti A, Rossini M, Gatti D, Nuti R, Minisola S; Italian Society for Osteoporosis, Mineral Metabolism and Bone Diseases (SIOMMMS). Treatment of Vitamin D Deficiency in Adults Importance of vitamin D Vitamin D is essential for skeletal growth and bone health.  |  COVID-19 is an emerging, rapidly evolving situation. Around 20% of adults and 8 to 24% of children may have low vitamin D status1. Participants in the remaining 26 trials had vitamin D insufficiency (less than 20 ng/mL).Vitamin D decreased mortality in all 56 trials analysed together (5,920/47,472 (12.5%) vs 6,077/47,814 (12.7%); RR 0.97 (95% confidence interval (CI) 0.94 to 0.99); P = 0.02; I(2) = 0%). Vitamin D, calcium or a combination of vitamin D and calcium for the treatment of nutritional rickets in children, Daily iron supplementation for prevention or treatment of iron deficiency anaemia in infants, children, and adolescents, Parenteral calcium for intensive care unit patients, Interventions for the prevention of nutritional rickets in term born children, Oral vitamin B12 compared with intramuscular vitamin B12 for vitamin B12 deficiency. Sunlight exposure inducing vitamin D production in the skin is main endogen source of vitamin D in the body but sunscreens may reduce skin synthesis by 90%. When different forms of vitamin D were assessed in separate analyses, only vitamin D3 decreased mortality (4,153/37,817 (11.0%) vs 4,340/38,110 (11.4%); RR 0.94 (95% CI 0.91 to 0.98); P = 0.002; I2 = 0%; 75,927 participants; 38 trials).

Pludowski P, Grant WB, Bhattoa HP, Bayer M, Povoroznyuk V, Rudenka E, Ramanau H, Varbiro S, Rudenka A, Karczmarewicz E, Lorenc R, Czech-Kowalska J, Konstantynowicz J. Int J Endocrinol. Calcium - General Range: 1000 mg to 1300 mg daily 2010 Mar-Apr;61(2):228-32. More than 8% of participants dropped out. Trial sequential analyses controlled the risk of random errors possibly caused by cumulative meta-analyses. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. 2012 Mar 14;(3):CD007176. Vitamin D in the healthy European paediatric population. Find out everything you need to know about weight loss drugs in our prescription weight loss pill guide. Vitamin D is synthesised in the skin as vitamin D3 (cholecalciferol) or is obtained from dietary sources or supplements as vitamin D3 or vitamin D2 (ergocalciferol). 2020 Aug 21;99(34):e21828. Participants in the remaining 26 trials had vitamin D insufficiency (less than 20 ng/mL).Vitamin D decreased mortality in all 56 trials analysed together (5,920/47,472 (12.5%) vs 6,077/47,814 (12.7%); RR 0.97 (95% confidence interval (CI) 0.94 to 0.99); P = 0.02; I2 = 0%). Our Cochrane systematic review from 2011, which analysed the influence of different forms of vitamin D on mortality, showed that vitamin D3 (cholecalciferol) decreased mortality. Should be taken with food to minimize gastrointestinal upset. A subgroup analysis of trials at high risk of bias suggested that vitamin D2 may even increase mortality, but this finding could be due to random errors. Ding Y, Chen D, Ding X, Wang G, Wan Y, Shen Q.

Vitamin D was administered for an average of 4.4 years. Epub 2014 Mar 26. Six review authors extracted data independently. endobj Trial sequential analyses controlled the risk of random errors possibly caused by cumulative meta-analyses. For dichotomous outcomes, we calculated the risk ratios (RRs). The mean proportion of women was 77%. Alfacalcidol and calcitriol increased the risk of hypercalcaemia (RR 3.18 (95% CI 1.17 to 8.68); P = 0.02; I2 = 17%; 710 participants; 3 trials). Vitamin D - General Range: 200 international units to 800 international units daily Last updated on May 31, 2019.

Because of risks of attrition bias originating from substantial dropout of participants and of outcome reporting bias due to a number of trials not reporting on mortality, as well as a number of other weaknesses in our evidence, further placebo-controlled randomised trials seem warranted. Participants could have been recruited from the general population or from patients diagnosed with a disease in a stable phase.

2020 Jun 15;2020:7562958. doi: 10.1155/2020/7562958. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Bjelakovic G, Gluud LL, Nikolova D, Whitfield K, Krstic G, Wetterslev J, Gluud C. Cochrane Database Syst Rev.
). eCollection 2020. 1 0 obj

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